Concomitant use of Crixivan with lovastatin or simvastatin is contraindicated due to an increased risk of myopathy including rhabdomyolysis. Caution should be exercised if Crixivan is used concurrently with atorvastatin or rosuvastatin. Titrate the atorvastatin and rosuvastatin doses carefully and use the lowest necessary dose with Crixivan. Some medical conditions may interact with indinavir. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
Indinavir is to be used only by the patient for whom it is prescribed. Do not share it with other people. ZERIT that is written for health professionals. How should I take indinavir?
Tell your doctor about any medicines you are taking or plan to take, including non-prescription medicines, herbal products including St. John's wort Hypericum perforatum or dietary supplements. CYP3A4 Inducers Strong: May increase the metabolism of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. ONGLYZA, talk with your healthcare provider.
Cersosimo MG, Lasala B, Folgar S, Micheli F "Epidural Lipomatosis Secondary to Indinavir in an HIV-Positive Patient. What should I avoid while taking alosetron Lotronex? There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Yeh KC, Deutsch PJ, Haddix H et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother.
Dose reduction of Crixivan to 600 mg every 8 hours should be considered when administering delavirdine 400 mg three times a day. Treatment regimens containing zidovudine were modified in a blinded manner with the optional addition of lamivudine median time: week 40. The median length of follow-up was 56 weeks with a maximum of 97 weeks. The study was terminated after a planned interim analysis, resulting in a median follow-up of 56 weeks and a maximum follow-up of 97 weeks. Store indinavir at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in the original bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Leave the desiccant in the bottle. Do not eat the desiccant. Keep indinavir out of the reach of children and away from pets. CHILDREN or before the patient's first menstrual period; safety and effectiveness in children have not been confirmed. Ketoconazole Systemic: May increase the serum concentration of Indinavir. Indinavir may increase the serum concentration of Ketoconazole Systemic. Management: Reduce the normal indinavir adult dose to 600 mg every 8 hours when given with ketoconazole. Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates. HIV-1 infection, including opportunistic infections. Flynn TE, Bricker LA "Myocardial infarction in HIV-infected men receiving protease inhibitors. Some of the side effects that can occur with indinavir may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Talk with your health provider. Dienogest: CYP3A4 Inhibitors Strong may increase the serum concentration of Dienogest. Spontaneous bleeding episodes have been reported in hemophiliac patients while receiving protease inhibitors. No causal relationship has been established, however, hemophiliacs should be monitored closely for bleeding during protease inhibitor therapy. Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach. North Chicago, IL; 2012 Feb. Rodwell GEJ, Maurer TA, Barger TG "Fat redistribution in HIV disease.
Ivacaftor: CYP3A4 Inhibitors Strong may increase the serum concentration of Ivacaftor. Management: Ivacaftor dose reductions are required; consult full monograph content for specific age- and weight-based recommendations. Dohme. Crixivan indinavir sulfate capsules prescribing information. Whitehouse Station, NJ; 2014 Jul. Fung HB, Pecini RA, Brown ST, Gropper CA "Indinavir-associated maculopapular eruption. ALERT: Find out about medicines that should NOT be taken with Crixivan. A Patient Package Insert PPI for Crixivan is available for patient information. Refer to the quetiapine prescribing information for initial dosing and titration of quetiapine. Gerberding J. Is antiretroviral treatment after percutaneous HIV exposure justified? rabeprazole
Plasma concentrations may be increased by CRIXIVAN. What are the possible side effects of ONGLYZA? DOXOrubicin Conventional: CYP3A4 Inhibitors Strong may increase the serum concentration of DOXOrubicin Conventional. Management: Seek alternatives to strong CYP3A4 inhibitors in patients treated with doxorubicin whenever possible. Radotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Radotinib. HIV-1 with reduced susceptibility to indinavir have been selected in vitro and have emerged during therapy with the drug. Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine. It is important to continue taking this medication as prescribed even if you feel well. To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. HIV RNA assays or using other sample credits. The body breaks down antipyrine to get rid of it. Some chemicals in marijuana might decrease how quickly the body breaks down antipyrine. This might increase antipyrine levels in the body and increase its effects and side effects. For optimal absorption, Crixivan should be administered without food but with water 1 hour before or 2 hours after a meal. Pimozide: CYP3A4 Inhibitors Strong may increase the serum concentration of Pimozide. If you take Crixivan with SPORANOX, your doctor may adjust the dose of Crixivan. slel.info silagra
Know the medicines you take. Acute hemolytic anemia, including fatalities, reported. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. How should I take Crixivan indinavir? Alitretinoin Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of Alitretinoin Systemic. Management: Consider reducing the alitretinoin dose to 10 mg when used together with strong CYP3A4 inhibitors.
IC 95. In general, higher levels of resistance were associated with the co-expression of greater numbers of substitutions, although their individual effects varied and were not additive. At least 3 amino acid substitutions must be present for phenotypic resistance to indinavir to reach measurable levels. May lead to loss of virologic response and possible resistance to Crixivan or to the class of protease inhibitors or other coadministered antiretroviral agents. ALPRAZolam: Indinavir may increase the serum concentration of ALPRAZolam. Cyclophosphamide. Specifically, the incidences of neutropenia, infection, and mucositis may be increased. Mirodenafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Mirodenafil. Management: Consider using a lower dose of mirodenafil when used with strong CYP3A4 inhibitors. NDC 0006-0571-43 unit-of-use bottles of 360 with desiccant. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Visnergarwala F, Krause KL, Musher DM. Severe diabetes associated with protease inhibitor therapy. Ann Intern Med. Tisdale M, Myers RE, Maschera B et al. Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors. Antimicrob Agents Chemother. Centers for Disease Control and Prevention. Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors. MMWR Morb Mortal Wkly Rep. Everolimus: CYP3A4 Inhibitors Strong may increase the serum concentration of Everolimus. Reyataz atazanavir sulfate Australian product information. Efavirenz: May decrease the serum concentration of Atovaquone. Management: Consider alternatives to the use of atovaquone with efavirenz when possible. If this combination must be used, monitor for evidence of reduced atovaquone clinical effectiveness. online eutirox in canada
The recommended dose for adults is 800 mg every eight hours. Tozzi V, Narcisco P, Sebastiani G, Frigiotti D, DAmato C "Effects of indinavir treatment on platelet and neutrophil counts in patients with advanced HIV disease. See text below for discussion of interaction. The atorvastatin and rosuvastatin doses should be carefully titrated; use the lowest dose necessary with careful monitoring during treatment with Crixivan. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking first with your doctor. Manfredi R, Calza L, Chiodo F "Gynecomastia associated with highly antiretroviral therapy. Can Crixivan be taken with other medications? It works by slowing or stopping the growth of or tumor cells. Hormonal birth control eg, birth control pills may not work as well while you are using indinavir. To prevent pregnancy, use an extra form of birth control eg, condoms. Bosutinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Bosutinib. ONGLYZA and seek medical advice promptly. Nilotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Nilotinib. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Read the Patient Information Leaflet if available from your before you start taking everolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; back, flank, or side pain; bloody or cloudy urine; change in the amount of urine produced; changes in appetite; chest, jaw, or arm pain; chills; confusion; dark urine; depression; fainting; fever; heartburn; ingrown toenails; joint pain; loss of appetite; numbness of the mouth; one-sided numbness or weakness; pain while urinating; pale stools; red, swollen, blistered, or peeling skin; severe or persistent stomach pain or upset; shortness of breath; speech problems; sudden, unusual sweating; swelling of the stomach; unusual hair loss; unusual paleness; unusual tiredness or weakness; unusually dry skin; vision changes; yellowing of the skin or eyes. Herry I, Bernard L, de Truchis P et al. Hypertrophy of the breasts in a patient treated with indinavir. Clin Infect Dis. isotrexin mail order now shopping
Protect from moisture. 1 Dispense and store in original container; the desiccant should remain in the original bottle. Lumefantrine: CYP3A4 Inhibitors Strong may increase the serum concentration of Lumefantrine. CI: 50%, 86% lower than that observed 6 weeks postpartum. Six of these 11 55% patients had mean indinavir plasma concentrations 8 hours post-dose C min below assay threshold of reliable quantification. Patients with asymptomatic severe leukocyturia should be followed closely and monitored frequently with urinalyses. Further diagnostic evaluation may be warranted, and discontinuation of Crixivan should be considered in all patients with severe leukocyturia. Shaughnessy MV. Emerging international consensus for use of antiretroviral therapy. Lancet. Reyataz atazanavir sulfate US prescribing information. Temsirolimus. Levels of sirolimus, the active metabolite, may be increased, likely due to inhibition of CYP-mediated metabolism. Concomitant use of fluticasone propionate and CRIXIVAN may increase plasma concentrations of fluticasone propionate. Use with caution. Consider alternatives to fluticasone propionate, particularly for long-term use. Cannabis: CYP3A4 Inhibitors Strong may increase the serum concentration of Cannabis. More specifically, tetrahydrocannabinol and cannabidiol serum concentrations may be increased. To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Alfuzosin: Protease Inhibitors may increase the serum concentration of Alfuzosin. Changes in body fat fat redistribution. Lapatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Lapatinib. Take indinavir on a regular schedule every 8 hours around the clock, unless your doctor tells you otherwise.
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AUC of a single 800 mg oral dose of indinavir and a 36% decrease in indinavir C max. Indinavir did not affect the pharmacokinetics of venlafaxine and ODV. The clinical significance of this finding is unknown. Zolpidem: CYP3A4 Inhibitors Strong may increase the serum concentration of Zolpidem. Lee D, Benson CA, Lewis CE, Grunfeld C, Scherzer R "Prevalence and factors associated with dry skin in HIV infection: the FRAM study. Do not skip pills even if you do not have sex very often. astonin
Alosetron blocks the action of a chemical called serotonin in the intestines. This slows the movement of stools bowel movements through the intestines. Read the Guide provided by your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Many other prescription and nonprescription medicines eg, used for aches or pain, allergies, asthma or other lung or breathing problems, blood thinning, blood vessel problems, cancer, Cushing syndrome, cystic fibrosis, depression or other mental or mood problems, diabetes, erectile dysfunction, gout, high blood pressure, high cholesterol, HIV infection, immune suppression, infections, inflammation, insomnia, irregular heartbeat or other heart problems, migraine headaches, narcotic addiction, nausea or vomiting, overactive bladder, PAH, seizures, stomach or bowel problems multivitamin products, and herbal or dietary supplements eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort may interact with indinavir.
Patient may experience headache, abdominal pain, back pain, vomiting, or nausea. Delta Coordinating Committee. Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet. Call your healthcare provider for medical advice about side effects. Company, Inc, West Point, PA: Personal communication. cordarone
The dosage of Crixivan should be reduced to 600 mg every 8 hours in patients with mild-to-moderate hepatic insufficiency due to cirrhosis. AIDS. N Engl J Med. According to the manufacturer, indinavir was identified as a component of the kidney stones from 8 of 12 patients in whom nephrolithiasis developed. It is not known whether an additional risk is incurred with the concomitant use of crystalluria-inducing medications such as sulfonamides.